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The upregulation of Trx1, however, did not seem to compensate fully for the loss of TRP14 activities, because when assessing cystine reduction using BODIPY-labeled cystine, which becomes fluorescent upon reduction of its disulfide (Pader et al, 2014), TRP14 deletion severely hampered the strong fluorescence seen in control cells (Fig

A recent study illustrated that trans-3-indoleacrylic acid, a tryptophan metabolite derived from the intestinal microbe P